The purpose of this paper was to examine the impacts of population explosion, misery index, access to adequate sanitation and improved water supply, economic development and electricity consumption on poverty SDG for 20 Sub-Saharan African countries. The study employed annual secondary balanced panel data sourced from World Bank development indicators covering 1990 to 2018. The results of the robust least square and panel least square estimates were reinforcing. The study found that poor access to water and high misery index amplified poverty. Also, access to improved sanitation, population growth, economic development and energy consumption per capita linked with significant poverty reduction in the region. Our empirical result further established some level of causation between poverty and its predictors except inflation. The implication of our findings is significant for policy direction and drive towards the attainment of poverty SDG in the region. To achieve this, countries in the area should increase the supply of improved water, create more jobs and formulate anti-inflation policies. Also, better electricity supply, economic development strategies, and the growth of the productive population were suggested for poverty eradication in the region.